Journal: NPJ Digital Medicine

Article Title: Digital biomarkers for non-motor symptoms in Parkinson’s disease: the state of the art

doi: 10.1038/s41746-024-01144-2

Figure Lengend Snippet: Digital biomarkers of non-motor symptoms currently available or under development

Article Snippet: , Wake-sleep rhythm , Wrist-worn actigraphy (Mini Mitter Actiwatch©-64), and smartphone , Longitudinal study, N = 265 anxiety and panic disorder. 9–14 years after baseline anxiety assessment, they performed one-week actigraphy which was used to predict anxiety after a total of up to 18 years follow-up. , Out-of-sample cross-validation demonstrates that the algorithm predicts symptom deterioration in individuals across a 17–18 year period with 84.6% sensitivity, 52.7% specificity, area under the curve = 0.696, accuracy = 68.7%. , Wake-sleep rhythm data collected across seven consecutive days. Prediction of symptom deterioration significant across 17–18 years. , Highly wearable, battery capacity unclear, uses proprietary software. , Actigraphy predicts anxiety longitudinally (up to 17–18 years). , .

Techniques: Control, Activity Assay, Marker, Software, Standard Deviation, Spectroscopy, Transmission Assay, Comparison, Sampling, Capsules, Muscles, Modification, Battery

Journal:

Article Title: Preflight Adjustment to Eastward Travel: 3 Days of Advancing Sleep with and without Morning Bright Light

doi: 10.1177/0748730403253585

Figure Lengend Snippet: Total sleep time and sleep onset latency, from sleep logs and from wrist actigraphy during baseline (days 2–6) and during the phase-advancing treatment (days 11–13). Values are means ± SEs.

Article Snippet: Subjects also wore an actigraphy monitor (Actiwatch 64, Mini Mitter, Bend, OR) on their nondominant wrist, except during showers and baths.

Techniques:

Journal: Journal of Biological Rhythms

Article Title: Evidence for Internal Misalignment of Circadian Rhythms in Youth With Emerging Mood Disorders

doi: 10.1177/07487304251349408

Figure Lengend Snippet: Timing of DLMO, core body temperature nadir, and cortisol peak in controls and youth with emerging mood disorders. Abbreviations: DLMO = dim light melatonin onset, Temp Nadir = Core Body Temperature Nadir. Boxplots display the median and interquartile range, dots represent individual data points, triangles represent individuals with non-24-h actigraphy patterns.

Article Snippet: Participants wore a wrist mounted actigraphy recording device (Actiwatch-64/L/2/Spectrum; Philips Respironics, Pittsburgh, USA; or GENEActiv; Activinsights, Kimbolton, UK) for between 5 and 22 days (median 13 days) prior to the in-lab circadian assessment.

Techniques:

Journal: Journal of Biological Rhythms

Article Title: Evidence for Internal Misalignment of Circadian Rhythms in Youth With Emerging Mood Disorders

doi: 10.1177/07487304251349408

Figure Lengend Snippet: Distribution of phase angle differences in controls and youth with emerging mood disorders. Abbreviations: DLMO = dim light melatonin onset; Temp = Core Body Temperature Nadir. Boxplots display the median and interquartile range, dots represent individual data points, triangles represent individuals with non-24-h actigraphy patterns.

Article Snippet: Participants wore a wrist mounted actigraphy recording device (Actiwatch-64/L/2/Spectrum; Philips Respironics, Pittsburgh, USA; or GENEActiv; Activinsights, Kimbolton, UK) for between 5 and 22 days (median 13 days) prior to the in-lab circadian assessment.

Techniques:

Journal: Journal of Biological Rhythms

Article Title: Evidence for Internal Misalignment of Circadian Rhythms in Youth With Emerging Mood Disorders

doi: 10.1177/07487304251349408

Figure Lengend Snippet: Timing of phase markers in youth with emerging mood disorders and internal circadian misalignment. Boxes and colored lines represent the timing of DLMO (blue), Core Temperature Nadir (red), and Cortisol Peak (green) relative to sleep midpoint. Dotted lines indicate missing data; for illustrative purposes, we have interpolated the mean for these missing values with the average of the mood disorder group. The mean timing for controls with normal circadian alignment (controls-circadian aligned), and individuals with emerging mood disorders and normal internal circadian alignment (mood disorder-circadian aligned) is displayed alongside individual data for those with internal circadian misalignment. C1 indicates a control participant with internal circadian misalignment. Participant M13 was missing actigraphy data for sleep midpoint estimation and was instead centered on the Mood Disorder group mean. Participants M14 and M15 did not have core body temperature nadir due to missing data. Participant M16 did not have cortisol peak due to missing data.

Article Snippet: Participants wore a wrist mounted actigraphy recording device (Actiwatch-64/L/2/Spectrum; Philips Respironics, Pittsburgh, USA; or GENEActiv; Activinsights, Kimbolton, UK) for between 5 and 22 days (median 13 days) prior to the in-lab circadian assessment.

Techniques: Control